Manuela G López Selected Research

Okadaic Acid

1/2022	Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
10/2019	Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture.
1/2019	1-(2',5'-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity.
2/2015	The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction.
9/2011	Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.
6/2011	N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
12/2005	Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors.

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Manuela G López Research Topics

Disease

23	Alzheimer Disease (Alzheimer's Disease) 09/2023 - 01/2004
20	Neuroblastoma 01/2023 - 01/2004
13	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 04/2009
11	Brain Ischemia (Cerebral Ischemia) 04/2017 - 08/2007
9	Stroke (Strokes) 01/2018 - 04/2009
8	Inflammation (Inflammations) 01/2022 - 08/2013
8	Ischemia 01/2020 - 08/2007
6	Neuroinflammatory Diseases 04/2021 - 01/2015
6	Infarction (Infarctions) 01/2019 - 04/2013
5	Hypoxia (Hypoxemia) 10/2020 - 07/2004
5	Pain (Aches) 01/2019 - 07/2008
4	Tauopathies 01/2022 - 01/2018
3	Reperfusion Injury 06/2013 - 08/2007
2	Major Depressive Disorder (Major Depressive Disorders) 11/2021 - 11/2019
2	Cognitive Dysfunction 01/2021 - 08/2019
2	Nervous System Diseases (Neurological Disorders) 01/2019 - 04/2015
2	Ischemic Stroke 01/2019 - 01/2018
2	Schizophrenia (Dementia Praecox) 05/2015 - 10/2014
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2015 - 01/2014
2	Vascular Diseases (Vascular Disease) 01/2011 - 08/2010
1	Disease Progression 04/2024
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2023
1	Hypersensitivity (Allergy) 01/2023
1	Neuralgia (Stump Neuralgia) 01/2023
1	Frontotemporal Dementia (Semantic Dementia) 01/2022
1	Body Weight (Weight, Body) 04/2021
1	Iron Overload 01/2021

Drug/Important Bio-Agent (IBA)

16	Neuroprotective AgentsIBA 01/2020 - 12/2005
10	MelatoninIBA 08/2019 - 05/2009
9	Galantamine (Galanthamine)FDA LinkGeneric 09/2013 - 01/2004
8	CalciumIBA 11/2021 - 10/2008
8	Oxygen (Dioxygen)IBA 01/2020 - 05/2011
8	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 05/2011
8	Cholinergic Agents (Cholinergics)IBA 10/2017 - 12/2007
7	Okadaic AcidIBA 01/2022 - 12/2005
7	AntioxidantsIBA 07/2020 - 05/2009
6	RotenoneIBA 10/2019 - 05/2009
6	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019 - 01/2004
6	Tacrine (Cognex)FDA Link 01/2015 - 12/2006
5	LigandsIBA 04/2024 - 05/2009
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2018
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2012
5	oligomycin AIBA 10/2019 - 07/2010
5	Glutamic Acid (Glutamate)FDA Link 01/2017 - 01/2006
3	1,4-dihydropyridine (dihydropyridine)IBA 07/2020 - 12/2006
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 10/2014
3	Peptides (Polypeptides)IBA 01/2019 - 01/2004
3	Amyloid (Amyloid Fibrils)IBA 01/2019 - 09/2004
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2016 - 02/2009
3	Amyloid beta-PeptidesIBA 02/2015 - 12/2005
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2015 - 12/2005
3	Nicotine FDA Link 10/2014 - 12/2005
3	AcetylcholinesteraseIBA 12/2006 - 01/2004
2	Formaldehyde (Formol)FDA Link 01/2023 - 07/2008
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 01/2019
2	EnzymesIBA 01/2022 - 08/2008
2	Ligand-Gated Ion ChannelsIBA 11/2021 - 10/2014
2	PNU-282987IBA 04/2021 - 10/2013
2	Phosphotransferases (Kinase)IBA 12/2020 - 07/2020
2	Superoxides (Superoxide)IBA 10/2020 - 01/2017
2	tau Proteins (tau Protein)IBA 07/2020 - 01/2006
2	Caspase 3 (Caspase-3)IBA 08/2019 - 02/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2019 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 01/2018
2	Heme (Haem)IBA 01/2018 - 08/2012
2	Protein Isoforms (Isoforms)IBA 01/2018 - 05/2015
2	Cholinesterases (Cholinesterase)IBA 04/2017 - 01/2015
2	Donepezil (Aricept)FDA LinkGeneric 04/2017 - 12/2005
2	GlutamatesIBA 04/2017 - 11/2009
2	ITH14001IBA 01/2017 - 01/2017
2	AminesIBA 02/2015 - 05/2014
2	Free RadicalsIBA 12/2010 - 12/2006
2	Memantine (Namenda)FDA Link 02/2009 - 07/2004
2	salicylhydroxamic acid (SHAM)IBA 02/2009 - 08/2007
1	AdipokinesIBA 09/2023
1	Hypnotics and Sedatives (Sedatives)IBA 01/2023
1	Gabapentin (Neurontin)FDA LinkGeneric 01/2023
1	Capsaicin (Zostrix)FDA Link 01/2023
1	DisaccharidesIBA 01/2023
1	Hyaluronic Acid (Hyaluronan)IBA 01/2023
1	Ruthenium RedIBA 01/2023
1	Streptozocin (Streptozotocin)FDA Link 01/2023
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2023
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	NADPH Oxidase 4IBA 01/2022
1	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA 01/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022
1	Purinergic P2X7 ReceptorsIBA 11/2021
1	Messenger RNA (mRNA)IBA 04/2021
1	LipopolysaccharidesIBA 04/2021
1	Chelating AgentsIBA 01/2021
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2021
1	IronIBA 01/2021
1	Leucine (L-Leucine)FDA Link 12/2020
1	Protein Kinases (Protein Kinase)IBA 12/2020
1	benzothiazoleIBA 12/2020
1	Therapeutic UsesIBA 12/2020

Therapy/Procedure

2	Therapeutics 01/2018 - 12/2010
1	Oral Administration 01/2023
1	Drug Therapy (Chemotherapy) 01/2023